Our research focus on molecular signaling pathways involved in breast cancer tumorigenesis and metastasis. We make us of cell line models to modulate signaling pathways by overexpression and silencing of specific targets using viral methods. We analyze interactions between signaling molecules and their effects on various cellular processes involved in tumorigenesis and metastasis including proliferation, transformation, invasion and migration.
Grants
| TUBITAK | A New Lab-on-a-CHIP device for early diagnosis of metastasis
The Scientific and Technological Research Council of Turkey |
| TUBITAK | Identification of novel Notch target genes that are mediators of Notch in inducing epithelial-mesenchymal transition and migration/invasion
The Scientific and Technological Research Council of Turkey |
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TUBITAK |
The role of IRF6 as a switch for the cell growth inhibitor or inducer functions of Notch signaling
The Scientific and Technological Research Council of Turkey |
| İYTE – BAP | Notch-IRF6 interaction in cell cycle regulation of breast epithelial cells
Izmir Institute of Technology |
| İYTE – BAP | Effects of Notch signaling on SLPI expression in breast cancer cell lines
Izmir Institute of Technology |
| İYTE – BAP | Understanding the tumor suppressor role of IRF6 and its effect on p63
Izmir Institute of Technology |