ÖZDEN YALÇIN RESEARCH GROUP
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Research

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Our research focus on molecular signaling pathways involved in breast cancer tumorigenesis and metastasis. We make us of cell line models to modulate signaling pathways by overexpression and silencing of specific targets using viral methods. We analyze interactions between signaling molecules and their effects on various cellular processes involved in tumorigenesis and metastasis including proliferation, transformation, invasion and migration.

Grants

 TUBITAK A New Lab-on-a-CHIP device for early diagnosis of metastasis

The Scientific and Technological Research Council of Turkey

TUBITAK Identification of novel Notch target genes that are mediators of Notch in inducing epithelial-mesenchymal transition and migration/invasion

The Scientific and Technological Research Council of Turkey

TUBITAK

The role of IRF6 as a switch for the cell growth inhibitor or inducer functions of Notch signaling

The Scientific and Technological Research Council of Turkey

İYTE – BAP Notch-IRF6 interaction in cell cycle regulation of breast epithelial cells

Izmir Institute of Technology

İYTE – BAP Effects of Notch signaling on SLPI expression in breast cancer cell lines

Izmir Institute of Technology

 İYTE – BAP  Understanding the tumor suppressor role of IRF6 and its effect on p63

Izmir Institute of Technology

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